New paper published in PNAS

New paper published in PNAS

Our paper, revealing long non-coding RNA MaIL1 as a component of the TLR4-TRIF immune signaling pathway is now out in PNAS. We reveal MaIL1 as a critical component of type I interferon-mediated innate antibacterial defense in human macrophages. The paper also reports previously unknown subclasses of long non-coding RNAs (lncRNAs), co-sedimenting with different cellular protein machineries, and describes a new workflow for lncRNA mechanistic investigation.
Improved lncRNA knockout method published

Improved lncRNA knockout method published

Check our recent publication introducing an improved Cas9-based method for silencing of long non-coding RNA genes: 'Cas9-mediated excision of proximal DNaseI/H3K4me3 signatures conferse robust silencing of microRNA and long non-coding RNA genes' Janga H, Aznaourova M, Boldt F, Damm K, Gr├╝nweller A, Schulte LN https://doi.org/10.1371/journal.pone.0193066