Check our recent publication introducing an improved Cas9-based method for silencing of long non-coding RNA genes:

'Cas9-mediated excision of proximal DNaseI/H3K4me3 signatures conferse robust silencing of microRNA and long non-coding RNA genes'

Janga H, Aznaourova M, Boldt F, Damm K, Grünweller A, Schulte LN


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