Our paper, revealing long non-coding RNA MaIL1 as a component of the TLR4-TRIF immune signaling pathway is now out in PNAS. We reveal MaIL1 as a critical component of type I interferon-mediated innate antibacterial defense in human macrophages. The paper also reports previously unknown subclasses of long non-coding RNAs (lncRNAs), co-sedimenting with different cellular protein machineries, and describes a new workflow for lncRNA mechanistic investigation.
Leon Schulte is now member of the German Center for Lung Research (DZL)
We published a short article in the GIT laboratory journal describing our new bacteria fluorescent labeling approach using the 6-TramTo-3 dye. Here is the link...
For our work on fluorescent dyes facilitating host-pathogen interaction studies we have been awarded the 2018 MarBiNa prize. We want to thank the Marburg Biotechnology and Nanotechnology Initiative for this honorable award.
We are pleased to announce the upcoming Minisymposium "Genomics approaches in RNA biology" which will be held at our institute on October 24th 2018. The RNA Salon series brings thogether scientist from the RNA field in the Rhein Main area. Please find the program and directions below: Program 5. RMU_RNA_Salon How to get to the BMFZ
A PhD position is currently available in our lab. The successful candidate will identify reulatory RNA networks in human inflammatory diseases. We offer a well-equiped lab, expertise in cutting edge techniques (e.g. RNA-Seq, CRISPR-screening, RNA-FISH, high resolution microscopy) and acccess to a broad network of excellent collaboration partners. For more information please read the job posting: job posting (pdf)
Our article entitled "A Far-Red Fluorescent DNA Binder Enables Interaction Studies of Live Multidrug-Resistant Pathogens and Host Cells" has been accepted for publication by Angewandte Chemie, one of the leading journals in chemistry. This interdiscplinary work by the Schulte and Vazquez labs describes a new far-red bacterial fluorescent dye, TramTO, suitable for FACS and microscopy analysis of the interplay of live bacterial pathogens with their host cells. We show that TramTO labeling may replace bacterial fluorescent protein-tagging methods in macrophage uptake assays with the advantages of a less time-consuming labeling strategy and the…
We are now member of the "Sonderforschungsbereich" SFB-TR84 - Innate Immunity of the Lung (https://www.sfb-tr84.de/). Our project will further elucidate the mechanistic implications of lncRNAs in the human mononuclear phagocyte system with an emphasis on innate defense against bacterial agents of pneumonia.
A joint symposium with representatives of the medical and chemical faculties of the Philipps-University Marburg and the Tongji University Shanghai will take place from May 23-25 2018 in Shanghai. The symposium will be part of the 'Marburg Days', taking place at the same time to foster the strategic partnership between both universities. PhD students and faculty members are welcome to join. Please do not hesitate to contact us. On behalf of the scientific coordinators, Leon Schulte (firstname.lastname@example.org)
A step-by-step protocol for our new long non-coding RNA gene knockout method has been deposited at protocols.io: http://dx.doi.org/10.17504/protocols.io.mmic44e