Great team achievement! Our paper on the role of lncRNAs in COVID-19 has been accepted for publication in PNAS. Using scRNAseq, we identified a lincRNA mechanism that promotes the expression of alarmins, which critically contribute to immune imbalances in COVID-19. Here's the link to the paper
Our preprint on the role of lncRNAs in COVID-19 is online. Using scRNAseq, we identified a lincRNA mechanism that promotes the expression of alarmins, which critically contribute to immune imbalances in COVID-19. https://doi.org/10.1101/2021.11.05.467458
We published several new papers / reviews on noncoding RNAs in immunity and genetic diseases and Salmonella virulence strategies: Schmerer N, Schulte LN Long noncoding RNAs in bacterial infection WIRES RNA, (IF 6.8), in press, http://doi.org/10.1002/wrna.1664 Linden G, Janga H, Franz M, Nist A, Stiewe T, Schmeck B, Vázquez O, Schulte LN Efficient antisense inhibition reveals microRNA-155 to restrain a late-myeloid inflammatory programme in primary human phagocytes RNA Biology, (IF 5.35), in press, https://doi.org/10.1080/15476286.2021.1885209 Walther K, Schulte LN. The role of lncRNAs in innate immunity and inflammation. RNA Biology (IF 5.35), 2021, doi:…
SFB-TR84 project prolongued, Fritz Thyssen Stiftung funding secured - great week so far.
Many thanks to all speakers and participants of our online RMU RNA Salon 2020 for the great presentations and discussions! Hopefully see you again in person in 2021.
Many thanks to the International Cytokine and Interferon Society (ICIS) and the Milstein Family for the Milstein Abstract Award, presented to Leon Schulte during the Cytokines 2020 meeting. It was an exciting conference with great speakers and many interesting Lightning Talks.
Our paper, revealing long non-coding RNA MaIL1 as a component of the TLR4-TRIF immune signaling pathway is now out in PNAS. We reveal MaIL1 as a critical component of type I interferon-mediated innate antibacterial defense in human macrophages. The paper also reports previously unknown subclasses of long non-coding RNAs (lncRNAs), co-sedimenting with different cellular protein machineries, and describes a new workflow for lncRNA mechanistic investigation.
Leon Schulte is now member of the German Center for Lung Research (DZL)
We published a short article in the GIT laboratory journal describing our new bacteria fluorescent labeling approach using the 6-TramTo-3 dye. Here is the link...